Per-Johan Jakobsson Group
About
We aim to explore targets and pathways in rheumatic and related diseases driven by inflammation using a pharmacological approach. We focus on the arachidonic acid cascade and the development of mPGES-1 inhibitors. We also investigate biomarkers in rheumatoid arthritis and systemic autoimmune inflammatory diseases and investigate e.g. the pathophysiological role of associated antigens and autoantibodies. Analytically, we e.g. perform proteomics, lipid metabolomics and cytokine profiling.
There is growing interest in society and in the scientific community to decipher the mechanisms of action of plant-based traditional Chinese medicine using evidence-based research methods. For this, we have established a research project called Joint Research Base for Chinese Medicine (JRBCM) at KI. The overall aim of JRBCM is to explore Chinese traditional herbal-based medicine as a source for evidence-based drug discovery and development. The JRBCM will assess the large amount of existing clinical data and explore the vast and unique resource of Chinese traditional medicine, with the ultimate aim of drug discovery and drug development for clinical use. The research is focused on isolation of bioactive compounds, exploration of their modes of action alone or in combinations, and ultimately development of novel medication for the treatment of and possibly prevention of rheumatoid arthritis.
Group Leader
Per-Johan Jakobsson, MD, specialist in rheumatology, Professor in Translational Inflammation Research, per-johan.jakobsson@ki.se
Group members
Marina Korotkova, docent, Senior scientist, marina.korotkova@ki.se
Louise Berg, docent, Senior lab manager, louise.berg@ki.se
Julia Steinmetz Späh, PhD, Postdoc, julia.steinmetzspah@ki.se
Janika Welzel, MSc, PhD student, janika.welzel@ki.se
Jianyang Liu, MSc, PhD student, jianyang.liu@ki.se
Karin Larsson, PhD, Senior scientist, karin.larsson@ki.se
Ahlem Zaghmi, PhD, Postdoc, ahlem.zaghmi@ki.se
Iro Chaitoglou, MSc, Lab technician, iro.chaitoglou@ki.se
Louisa Brieskorn, MSc, Lab technician, louisa.brieskorn@ki.se
Liyan Mei, MSc, Visiting scientist, liyan.mei@ki.se
Erdem Aybay, MSc, PhD student, erdem.aybay@ki.se
Sanjay Boddul, PhD, Senior scientist, sanjaykumar.boddul@ki.se
Sabreen Alabbasi, MSc, lab technician, sabreen.alabbasi@ki.se
Helena Idborg, PhD, Senior scientist, helena.idborg@ki.se
PhD theses from the lab
Julia Steinmetz-Späh, 2023 https://openarchive.ki.se/xmlui/handle/10616/48324
Charlotta Preger, 2022 https://openarchive.ki.se/xmlui/handle/10616/48069
Filip Bergqvist, 2019 https://openarchive.ki.se/xmlui/handle/10616/46768
Joan Raouf, 2017 https://openarchive.ki.se/xmlui/handle/10616/45508
Patrick Leclerc, 2012 https://openarchive.ki.se/xmlui/handle/10616/41554
Sven-Christian Pawelzik, 2010 https://openarchive.ki.se/xmlui/handle/10616/40357
Marie Westman, 2005 https://openarchive.ki.se/xmlui/handle/10616/43487
Selected publications
Full list of publications: https://www.researchgate.net/profile/Per-Johan-Jakobsson