Hans Grönlund Group

Central to our research is the design and production of proteins for analyses of pathogenic antibodies and immune cells. The goal is to provide novel remedies applicable for clinical use. Therefore we adopt a translational research approach; we have established collaboration with clinicians, SciLife lab, biotechnical and medical companies, as well as academic research groups in Sweden and abroad. All our efforts aim to improve the quality of life for patients.

Hans Grönlund, principal researcher, associate professor, hans.gronlund@ki.se

Long Jiang, postdoc, long.jiang@ki.se

Nathaniel Alvin Sanjaya, affiliated to research, nathaniel.alvin.sanjaya@ki.se

Adela Kiessling, PhD student, adela.kiessling@ki.se

Alejandro Fernandez-Woodbridge, affiliated to research, alejandro.fernandez@ki.se

Sofia Berglund, affiliated to research, sofia.berglund@ki.se

Sara Dahmani, affiliated to research, sara.dahmani@ki.se

Birce Akpinar, affiliated to research, birce.akpinar@ki.se

Erik Holmgren, affiliated to research, erik.holmgren@ki.se

Olivia Thomas Team

The impact of hybrid immunity on immune responses after SARS-CoV-2 vaccination in persons with multiple sclerosis treated with disease-modifying therapies.
Rabenstein M, Thomas OG, Carlin G, Khademi M, Högelin KA, Malmeström C, Axelsson M, Brandt AF, Gafvelin G, Grönlund H, Kockum I, Piehl F, Lycke J, Olsson T, Hessa T. Eur J Neurol. 2023 Dec;30(12):3789-3798. doi:10.1111/ene.16015. Epub 2023 Aug 24. PMID: 37522464.

Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis.
Thomas OG*, Bronge M*, Tengvall K, Akpinar B, Nilsson OB, Holmgren E, Hessa T, Gafvelin G, Khademi M, Alfredsson L, Martin R, Guerreiro-Cacais AO, Grönlund H, Olsson T, Kockum I. Sci Adv. 2023 May 19;9(20):eadg3032. doi:10.1126/sciadv.adg3032. Epub 2023 May 17. PMID: 37196088; PMCID: PMC10191428.

Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis.
Bronge M, Högelin KA, Thomas OG, Ruhrmann S, Carvalho-Queiroz C, Nilsson OB, Kaiser A, Zeitelhofer M, Holmgren E, Linnerbauer M, Adzemovic MZ, Hellström C, Jelcic I, Liu H, Nilsson P, Hillert J, Brundin L, Fink K, Kockum I, Tengvall K, Martin R, Tegel H, Gräslund T, Al Nimer F, Guerreiro Cacais AO, Khademi M, Gafvelin G, Olsson T, Grönlund H. Sci Adv. 2022 Apr 29;8(17):eabn1823. doi: 10.1126/sciadv.abn1823. Epub 2022 Apr 27. PMID: 35476434; PMCID: PMC9045615.

Sensitive detection of antigen-specific T-cells using bead-bound antigen for in vitro re-stimulation.
Bronge M, Kaiser A, Carvalho-Queiroz C, Nilsson OB, Ruhrmann S, Holmgren E, Olsson T, Gafvelin G, Grönlund H. MethodsX. 2019 Jul 8;6:1635-1641. doi: 10.1016/j.mex.2019.07.004. PMID: 31367530; PMCID: PMC6651840.

Myelin oligodendrocyte glycoprotein revisited-sensitive detection of MOG-specific T-cells in multiple sclerosis.
Bronge M, Ruhrmann S, Carvalho-Queiroz C, Nilsson OB, Kaiser A, Holmgren E, Macrini C, Winklmeier S, Meinl E, Brundin L, Khademi M, Olsson T, Gafvelin G, Grönlund H. J Autoimmun. 2019 Aug;102:38-49. doi: 10.1016/j.jaut.2019.04.013. Epub 2019 May 1. PMID: 31054941.